In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs, conventional multiple instance learning (MIL) methods rely on aggregation functions to derive slide-level (bag-level) predictions from patch representations, which require extensive bag-level labels for training. In contrast, VLM-based approaches excel at aligning visual embeddings of patches with candidate class text prompts but lack essential pathological prior knowledge. Our method distinguishes itself by utilizing pathological prior knowledge from language models to identify crucial local tissue types (patches) for WSI classification, integrating this within a VLM-based MIL framework. Our approach effectively aligns patch images with tissue types, and we fine-tune our model via prompt learning using only a few labeled WSIs per category. Experimentation on real-world pathological WSI datasets and ablation studies highlight our method's superior performance over existing MIL- and VLM-based methods in few-shot WSI classification tasks. Our code is publicly available at https://github.com/LTS5/SLIP.
Prior research on out-of-distribution detection (OoDD) has primarily focused on single-modality models. Recently, with the advent of large-scale pretrained vision-language models such as CLIP, OoDD methods utilizing such multi-modal representations through zero-shot and prompt learning strategies have emerged. However, these methods typically involve either freezing the pretrained weights or only partially tuning them, which can be suboptimal for downstream datasets. In this paper, we highlight that multi-modal fine-tuning (MMFT) can achieve notable OoDD performance. Despite some recent works demonstrating the impact of fine-tuning methods for OoDD, there remains significant potential for performance improvement. We investigate the limitation of na\"ive fine-tuning methods, examining why they fail to fully leverage the pretrained knowledge. Our empirical analysis suggests that this issue could stem from the modality gap within in-distribution (ID) embeddings. To address this, we propose a training objective that enhances cross-modal alignment by regularizing the distances between image and text embeddings of ID data. This adjustment helps in better utilizing pretrained textual information by aligning similar semantics from different modalities (i.e., text and image) more closely in the hyperspherical representation space. We theoretically demonstrate that the proposed regularization corresponds to the maximum likelihood estimation of an energy-based model on a hypersphere. Utilizing ImageNet-1k OoD benchmark datasets, we show that our method, combined with post-hoc OoDD approaches leveraging pretrained knowledge (e.g., NegLabel), significantly outperforms existing methods, achieving state-of-the-art OoDD performance and leading ID accuracy.
Multi-species animal pose estimation has emerged as a challenging yet critical task, hindered by substantial visual diversity and uncertainty. This paper challenges the problem by efficient prompt learning for Vision-Language Pretrained (VLP) models, \textit{e.g.} CLIP, aiming to resolve the cross-species generalization problem. At the core of the solution lies in the prompt designing, probabilistic prompt modeling and cross-modal adaptation, thereby enabling prompts to compensate for cross-modal information and effectively overcome large data variances under unbalanced data distribution. To this end, we propose a novel probabilistic prompting approach to fully explore textual descriptions, which could alleviate the diversity issues caused by long-tail property and increase the adaptability of prompts on unseen category instance. Specifically, we first introduce a set of learnable prompts and propose a diversity loss to maintain distinctiveness among prompts, thus representing diverse image attributes. Diverse textual probabilistic representations are sampled and used as the guidance for the pose estimation. Subsequently, we explore three different cross-modal fusion strategies at spatial level to alleviate the adverse impacts of visual uncertainty. Extensive experiments on multi-species animal pose benchmarks show that our method achieves the state-of-the-art performance under both supervised and zero-shot settings. The code is available at https://github.com/Raojiyong/PPAP.
We introduce Low-Shot Open-Set Domain Generalization (LSOSDG), a novel paradigm unifying low-shot learning with open-set domain generalization (ODG). While prompt-based methods using models like CLIP have advanced DG, they falter in low-data regimes (e.g., 1-shot) and lack precision in detecting open-set samples with fine-grained semantics related to training classes. To address these challenges, we propose OSLOPROMPT, an advanced prompt-learning framework for CLIP with two core innovations. First, to manage limited supervision across source domains and improve DG, we introduce a domain-agnostic prompt-learning mechanism that integrates adaptable domain-specific cues and visually guided semantic attributes through a novel cross-attention module, besides being supported by learnable domain- and class-generic visual prompts to enhance cross-modal adaptability. Second, to improve outlier rejection during inference, we classify unfamiliar samples as "unknown" and train specialized prompts with systematically synthesized pseudo-open samples that maintain fine-grained relationships to known classes, generated through a targeted query strategy with off-the-shelf foundation models. This strategy enhances feature learning, enabling our model to detect open samples with varied granularity more effectively. Extensive evaluations across five benchmarks demonstrate that OSLOPROMPT establishes a new state-of-the-art in LSOSDG, significantly outperforming existing methods.
Contrastive Language-Image Pretraining (CLIP) has shown impressive zero-shot performance on image classification. However, state-of-the-art methods often rely on fine-tuning techniques like prompt learning and adapter-based tuning to optimize CLIP's performance. The necessity for fine-tuning significantly limits CLIP's adaptability to novel datasets and domains. This requirement mandates substantial time and computational resources for each new dataset. To overcome this limitation, we introduce simple yet effective training-free approaches, Single-stage LMM Augmented CLIP (SLAC) and Two-stage LMM Augmented CLIP (TLAC), that leverages powerful Large Multimodal Models (LMMs), such as Gemini, for image classification. The proposed methods leverages the capabilities of pre-trained LMMs, allowing for seamless adaptation to diverse datasets and domains without the need for additional training. Our approaches involve prompting the LMM to identify objects within an image. Subsequently, the CLIP text encoder determines the image class by identifying the dataset class with the highest semantic similarity to the LLM predicted object. Our models achieved superior accuracy on 9 of 11 base-to-novel datasets, including ImageNet, SUN397, and Caltech101, while maintaining a strictly training-free paradigm. Our TLAC model achieved an overall accuracy of 83.44%, surpassing the previous state-of-the-art few-shot methods by a margin of 6.75%. Compared to other training-free approaches, our TLAC method achieved 83.6% average accuracy across 13 datasets, a 9.7% improvement over the previous methods. Our Code is available at https://github.com/ans92/TLAC
Text-to-image person re-identification (ReID) aims to retrieve the images of an interested person based on textual descriptions. One main challenge for this task is the high cost in manually annotating large-scale databases, which affects the generalization ability of ReID models. Recent works handle this problem by leveraging Multi-modal Large Language Models (MLLMs) to describe pedestrian images automatically. However, the captions produced by MLLMs lack diversity in description styles. To address this issue, we propose a Human Annotator Modeling (HAM) approach to enable MLLMs to mimic the description styles of thousands of human annotators. Specifically, we first extract style features from human textual descriptions and perform clustering on them. This allows us to group textual descriptions with similar styles into the same cluster. Then, we employ a prompt to represent each of these clusters and apply prompt learning to mimic the description styles of different human annotators. Furthermore, we define a style feature space and perform uniform sampling in this space to obtain more diverse clustering prototypes, which further enriches the diversity of the MLLM-generated captions. Finally, we adopt HAM to automatically annotate a massive-scale database for text-to-image ReID. Extensive experiments on this database demonstrate that it significantly improves the generalization ability of ReID models.
Many studies have concentrated on constructing supervised models utilizing paired datasets for image denoising, which proves to be expensive and time-consuming. Current self-supervised and unsupervised approaches typically rely on blind-spot networks or sub-image pairs sampling, resulting in pixel information loss and destruction of detailed structural information, thereby significantly constraining the efficacy of such methods. In this paper, we introduce Prompt-SID, a prompt-learning-based single image denoising framework that emphasizes preserving of structural details. This approach is trained in a self-supervised manner using downsampled image pairs. It captures original-scale image information through structural encoding and integrates this prompt into the denoiser. To achieve this, we propose a structural representation generation model based on the latent diffusion process and design a structural attention module within the transformer-based denoiser architecture to decode the prompt. Additionally, we introduce a scale replay training mechanism, which effectively mitigates the scale gap from images of different resolutions. We conduct comprehensive experiments on synthetic, real-world, and fluorescence imaging datasets, showcasing the remarkable effectiveness of Prompt-SID. Our code will be released at https://github.com/huaqlili/Prompt-SID.
Large pre-trained vision-language models (VLMs) offer a promising approach to leveraging human language for enhancing downstream tasks. However, VLMs such as CLIP face significant limitation: its performance is highly sensitive to prompt template design. Although prompt learning methods can address the sensitivity issue by replacing natural language prompts with learnable ones, they are incomprehensible to humans. Ensuring consistent performance across various prompt templates enables models to adapt seamlessly to diverse phrasings, enhancing their ability to handle downstream tasks without requiring extensive prompt engineering. In this work, we introduce the RobustPrompt Benchmark, a systematic benchmark to evaluate robustness to different prompt templates for VLMs. It includes a dataset with hundreds of carefully designed prompt templates, divided into six types, covering a wide variety of commonly used templates. Beside the benchmark, we propose Modeling Variants of Prompts (MVP), a simple yet effective method that mitigates sensitivity by modeling variants of prompt structures. The innovation of MVP lies in decoupling prompts into templates and class names, and using Variational Autoencoders (VAE) to model the distribution of diverse prompt structures. Experiments across 11 datasets demonstrate that MVP can greatly enhance model robustness to variations in input prompts without a drop in performance. The code is available at https://github.com/liaolea/MVP.
Universal adverse weather removal (UAWR) seeks to address various weather degradations within a unified framework. Recent methods are inspired by prompt learning using pre-trained vision-language models (e.g., CLIP), leveraging degradation-aware prompts to facilitate weather-free image restoration, yielding significant improvements. In this work, we propose CyclicPrompt, an innovative cyclic prompt approach designed to enhance the effectiveness, adaptability, and generalizability of UAWR. CyclicPrompt Comprises two key components: 1) a composite context prompt that integrates weather-related information and context-aware representations into the network to guide restoration. This prompt differs from previous methods by marrying learnable input-conditional vectors with weather-specific knowledge, thereby improving adaptability across various degradations. 2) The erase-and-paste mechanism, after the initial guided restoration, substitutes weather-specific knowledge with constrained restoration priors, inducing high-quality weather-free concepts into the composite prompt to further fine-tune the restoration process. Therefore, we can form a cyclic "Prompt-Restore-Prompt" pipeline that adeptly harnesses weather-specific knowledge, textual contexts, and reliable textures. Extensive experiments on synthetic and real-world datasets validate the superior performance of CyclicPrompt. The code is available at: https://github.com/RongxinL/CyclicPrompt.
Vision-language models (VLMs) such as CLIP demonstrate strong performance but struggle when adapted to downstream tasks. Prompt learning has emerged as an efficient and effective strategy to adapt VLMs while preserving their pre-trained knowledge. However, existing methods still lead to overfitting and degrade zero-shot generalization. To address this challenge, we propose an optimal transport (OT)-guided prompt learning framework that mitigates forgetting by preserving the structural consistency of feature distributions between pre-trained and fine-tuned models. Unlike conventional point-wise constraints, OT naturally captures cross-instance relationships and expands the feasible parameter space for prompt tuning, allowing a better trade-off between adaptation and generalization. Our approach enforces joint constraints on both vision and text representations, ensuring a holistic feature alignment. Extensive experiments on benchmark datasets demonstrate that our simple yet effective method can outperform existing prompt learning strategies in base-to-novel generalization, cross-dataset evaluation, and domain generalization without additional augmentation or ensemble techniques. The code is available at https://github.com/ChongQingNoSubway/Prompt-OT
Cardiovascular magnetic resonance (CMR) imaging offers diverse contrasts for non-invasive assessment of cardiac function and myocardial characterization. However, CMR often requires the acquisition of many contrasts, and each contrast takes a considerable amount of time. The extended acquisition time will further increase the susceptibility to motion artifacts. Existing deep learning-based reconstruction methods have been proven to perform well in image reconstruction tasks, but most of them are designed for specific acquisition modality or dedicated imaging parameter, which limits their ability to generalize across a variety of scan scenarios. To address this issue, the CMRxRecon2024 challenge consists of two specific tasks: Task 1 focuses on a modality-universal setting, evaluating the out-of-distribution generalization of existing learning-based models, while Task 2 follows a k-space sampling-universal setting, assessing the all-in-one adaptability of universal models. Main contributions of this challenge include providing the largest publicly available multi-modality, multi-view cardiac k-space dataset; and developing an open benchmarking platform for algorithm evaluation and shared code library for data processing. In addition, through a detailed analysis of the results submitted to the challenge, we have also made several findings, including: 1) adaptive prompt-learning embedding is an effective means for achieving strong generalization in reconstruction models; 2) enhanced data consistency based on physics-informed networks is also an effective pathway toward a universal model; 3) traditional evaluation metrics have limitations when assessing ground-truth references with moderate or lower image quality, highlighting the need for subjective evaluation methods. This challenge attracted 200 participants from 18 countries, aimed at promoting their translation into clinical practice.
Contrast-enhanced magnetic resonance imaging (CE-MRI) is crucial for tumor detection and diagnosis, but the use of gadolinium-based contrast agents (GBCAs) in clinical settings raises safety concerns due to potential health risks. To circumvent these issues while preserving diagnostic accuracy, we propose a novel Transformer with Localization Prompts (TLP) framework for synthesizing CE-MRI from non-contrast MR images. Our architecture introduces three key innovations: a hierarchical backbone that uses efficient Transformer to process multi-scale features; a multi-stage fusion system consisting of Local and Global Fusion modules that hierarchically integrate complementary information via spatial attention operations and cross-attention mechanisms, respectively; and a Fuzzy Prompt Generation (FPG) module that enhances the TLP model's generalization by emulating radiologists' manual annotation through stochastic feature perturbation. The framework uniquely enables interactive clinical integration by allowing radiologists to input diagnostic prompts during inference, synergizing artificial intelligence with medical expertise. This research establishes a new paradigm for contrast-free MRI synthesis while addressing critical clinical needs for safer diagnostic procedures. Codes are available at https://github.com/ChanghuiSu/TLP.
Pre-trained vision-language models are able to interpret visual concepts and language semantics. Prompt learning, a method of constructing prompts for text encoders or image encoders, elicits the potentials of pre-trained models and readily adapts them to new scenarios. Compared to fine-tuning, prompt learning enables the model to achieve comparable or better performance using fewer trainable parameters. Besides, prompt learning freezes the pre-trained model and avoids the catastrophic forgetting issue in the fine-tuning. Continuous prompts inserted into the input of every transformer layer (i.e. deep prompts) can improve the performances of pre-trained models on downstream tasks. For i-th transformer layer, the inserted prompts replace previously inserted prompts in the $(i-1)$-th layer. Although the self-attention mechanism contextualizes newly inserted prompts for the current layer and embeddings from the previous layer's output, removing all inserted prompts from the previous layer inevitably loses information contained in the continuous prompts. In this work, we propose Modular Prompt Learning (MPL) that is designed to promote the preservation of information contained in the inserted prompts. We evaluate the proposed method on base-to-new generalization and cross-dataset tasks. On average of 11 datasets, our method achieves 0.7% performance gain on the base-to-new generalization task compared to the state-of-the-art method. The largest improvement on the individual dataset is 10.7% (EuroSAT dataset).
Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models for few-shot pathology classification. We first extend the Prov-GigaPath vision foundation model, pre-trained on 1.3 billion pathology image tiles, into a vision-language model by adding adaptors and aligning it with medical text encoders via contrastive learning on 923K image-text pairs. The model is then used to extract visual features and text embeddings from few-shot annotations and fine-tunes with learnable prompt embeddings. Unlike prior methods that combine prompts with frozen features using prefix embeddings or self-attention, we propose multi-granular attention that compares interactions between learnable prompts with individual image patches and groups of them. This approach improves the model's ability to capture both fine-grained details and broader context, enhancing its recognition of complex patterns across sub-regions. To further improve accuracy, we leverage (unbalanced) optimal transport-based visual-text distance to secure model robustness by mitigating perturbations that might occur during the data augmentation process. Empirical experiments on lung, kidney, and breast pathology modalities validate the effectiveness of our approach; thereby, we surpass several of the latest competitors and consistently improve performance across diverse architectures, including CLIP, PLIP, and Prov-GigaPath integrated PLIP. We release our implementations and pre-trained models at this MGPATH.
Most existing Knowledge Graph Question Answering (KGQA) approaches are designed for a specific KG, such as Wikidata, DBpedia or Freebase. Due to the heterogeneity of the underlying graph schema, topology and assertions, most KGQA systems cannot be transferred to unseen Knowledge Graphs (KGs) without resource-intensive training data. We present OntoSCPrompt, a novel Large Language Model (LLM)-based KGQA approach with a two-stage architecture that separates semantic parsing from KG-dependent interactions. OntoSCPrompt first generates a SPARQL query structure (including SPARQL keywords such as SELECT, ASK, WHERE and placeholders for missing tokens) and then fills them with KG-specific information. To enhance the understanding of the underlying KG, we present an ontology-guided, hybrid prompt learning strategy that integrates KG ontology into the learning process of hybrid prompts (e.g., discrete and continuous vectors). We also present several task-specific decoding strategies to ensure the correctness and executability of generated SPARQL queries in both stages. Experimental results demonstrate that OntoSCPrompt performs as well as SOTA approaches without retraining on a number of KGQA datasets such as CWQ, WebQSP and LC-QuAD 1.0 in a resource-efficient manner and can generalize well to unseen domain-specific KGs like DBLP-QuAD and CoyPu KG Code: \href{https://github.com/LongquanJiang/OntoSCPrompt}{https://github.com/LongquanJiang/OntoSCPrompt}
Blind dehazed image quality assessment (BDQA), which aims to accurately predict the visual quality of dehazed images without any reference information, is essential for the evaluation, comparison, and optimization of image dehazing algorithms. Existing learning-based BDQA methods have achieved remarkable success, while the small scale of DQA datasets limits their performance. To address this issue, in this paper, we propose to adapt Contrastive Language-Image Pre-Training (CLIP), pre-trained on large-scale image-text pairs, to the BDQA task. Specifically, inspired by the fact that the human visual system understands images based on hierarchical features, we take global and local information of the dehazed image as the input of CLIP. To accurately map the input hierarchical information of dehazed images into the quality score, we tune both the vision branch and language branch of CLIP with prompt learning. Experimental results on two authentic DQA datasets demonstrate that our proposed approach, named CLIP-DQA, achieves more accurate quality predictions over existing BDQA methods. The code is available at https://github.com/JunFu1995/CLIP-DQA.
Biological relation networks contain rich information for understanding the biological mechanisms behind the relationship of entities such as genes, proteins, diseases, and chemicals. The vast growth of biomedical literature poses significant challenges updating the network knowledge. The recent Biomedical Relation Extraction Dataset (BioRED) provides valuable manual annotations, facilitating the develop-ment of machine-learning and pre-trained language model approaches for automatically identifying novel document-level (inter-sentence context) relationships. Nonetheless, its annotations lack directionality (subject/object) for the entity roles, essential for studying complex biological networks. Herein we annotate the entity roles of the relationships in the BioRED corpus and subsequently propose a novel multi-task language model with soft-prompt learning to jointly identify the relationship, novel findings, and entity roles. Our results in-clude an enriched BioRED corpus with 10,864 directionality annotations. Moreover, our proposed method outperforms existing large language models such as the state-of-the-art GPT-4 and Llama-3 on two benchmarking tasks. Our source code and dataset are available at https://github.com/ncbi-nlp/BioREDirect.
Research on continual learning in multi-modal tasks has been receiving increasing attention. However, most existing work overlooks the explicit cross-modal and cross-task interactions. In this paper, we innovatively propose the Low-rank Prompt Interaction (LPI) to address this general problem of multi-modal understanding, which considers both cross-modal and cross-task interactions. Specifically, as for the former, we employ multi-modal correlation modules for corresponding Transformer layers. Considering that the training parameters scale to the number of layers and tasks, we propose low-rank interaction-augmented decomposition to avoid memory explosion while enhancing the cross-modal association through sharing and separating common-specific low-rank factors. In addition, due to the multi-modal semantic differences carried by the low-rank initialization, we adopt hierarchical low-rank contrastive learning to ensure training robustness. As for the latter, we initially employ a visual analysis and identify that different tasks have clear distinctions in proximity. Therefore, we introduce explicit task contrastive constraints in the prompt learning process based on task semantic distances. Experiments on two retrieval tasks show performance improvements with the introduction of a minimal number of parameters, demonstrating the effectiveness of our method. Code is available at https://github.com/Kelvin-ywc/LPI.
Weakly supervised object localization (WSOL) using classification models trained with only image-class labels remains an important challenge in computer vision. Given their reliance on classification objectives, traditional WSOL methods like class activation mapping focus on the most discriminative object parts, often missing the full spatial extent. In contrast, recent WSOL methods based on vision-language models like CLIP require ground truth classes or external classifiers to produce a localization map, limiting their deployment in downstream tasks. Moreover, methods like GenPromp attempt to address these issues but introduce considerable complexity due to their reliance on conditional denoising processes and intricate prompt learning. This paper introduces Text Distillation for Localization (TeD-Loc), an approach that directly distills knowledge from CLIP text embeddings into the model backbone and produces patch-level localization. Multiple instance learning of these image patches allows for accurate localization and classification using one model without requiring external classifiers. Such integration of textual and visual modalities addresses the longstanding challenge of achieving accurate localization and classification concurrently, as WSOL methods in the literature typically converge at different epochs. Extensive experiments show that leveraging text embeddings and localization cues provides a cost-effective WSOL model. TeD-Loc improves Top-1 LOC accuracy over state-of-the-art models by about 5% on both CUB and ILSVRC datasets, while significantly reducing computational complexity compared to GenPromp.
CLIP (Contrastive Language-Image Pre-training) has attained great success in pattern recognition and computer vision. Transferring CLIP to downstream tasks (e.g. zero- or few-shot classification) is a hot topic in multimodal learning. However, current studies primarily focus on either prompt learning for text or adapter tuning for vision, without fully exploiting the complementary information and correlations among image-text pairs. In this paper, we propose an Image Description Enhanced CLIP-Adapter (IDEA) method to adapt CLIP to few-shot image classification tasks. This method captures fine-grained features by leveraging both visual features and textual descriptions of images. IDEA is a training-free method for CLIP, and it can be comparable to or even exceeds state-of-the-art models on multiple tasks. Furthermore, we introduce Trainable-IDEA (T-IDEA), which extends IDEA by adding two lightweight learnable components (i.e., a projector and a learnable latent space), further enhancing the model's performance and achieving SOTA results on 11 datasets. As one important contribution, we employ the Llama model and design a comprehensive pipeline to generate textual descriptions for images of 11 datasets, resulting in a total of 1,637,795 image-text pairs, named "IMD-11". Our code and data are released at https://github.com/FourierAI/IDEA.