Deciphering language from brain activity is a crucial task in brain-computer interface (BCI) research. Non-invasive cerebral signaling techniques including electroencephalography (EEG) and magnetoencephalography (MEG) are becoming increasingly popular due to their safety and practicality, avoiding invasive electrode implantation. However, current works under-investigated three points: 1) a predominant focus on EEG with limited exploration of MEG, which provides superior signal quality; 2) poor performance on unseen text, indicating the need for models that can better generalize to diverse linguistic contexts; 3) insufficient integration of information from other modalities, which could potentially constrain our capacity to comprehensively understand the intricate dynamics of brain activity. This study presents a novel approach for translating MEG signals into text using a speech-decoding framework with multiple alignments. Our method is the first to introduce an end-to-end multi-alignment framework for totally unseen text generation directly from MEG signals. We achieve an impressive BLEU-1 score on the $\textit{GWilliams}$ dataset, significantly outperforming the baseline from 5.49 to 10.44 on the BLEU-1 metric. This improvement demonstrates the advancement of our model towards real-world applications and underscores its potential in advancing BCI research. Code is available at $\href{https://github.com/NeuSpeech/MAD-MEG2text}{https://github.com/NeuSpeech/MAD-MEG2text}$.
Electroencephalography (EEG) motor imagery (MI) classification is a fundamental, yet challenging task due to the variation of signals between individuals i.e., inter-subject variability. Previous approaches try to mitigate this using task-specific (TS) EEG signals from the target subject in training. However, recording TS EEG signals requires time and limits its applicability in various fields. In contrast, resting state (RS) EEG signals are a viable alternative due to ease of acquisition with rich subject information. In this paper, we propose a novel subject-adaptive transfer learning strategy that utilizes RS EEG signals to adapt models on unseen subject data. Specifically, we disentangle extracted features into task- and subject-dependent features and use them to calibrate RS EEG signals for obtaining task information while preserving subject characteristics. The calibrated signals are then used to adapt the model to the target subject, enabling the model to simulate processing TS EEG signals of the target subject. The proposed method achieves state-of-the-art accuracy on three public benchmarks, demonstrating the effectiveness of our method in cross-subject EEG MI classification. Our findings highlight the potential of leveraging RS EEG signals to advance practical brain-computer interface systems. The code is available at https://github.com/SionAn/MICCAI2024-ResTL.
Brain-computer interface (BCI) systems facilitate unique communication between humans and computers, benefiting severely disabled individuals. Despite decades of research, BCIs are not fully integrated into clinical and commercial settings. It's crucial to assess and explain BCI performance, offering clear explanations for potential users to avoid frustration when it doesn't work as expected. This work investigates the efficacy of different deep learning and Riemannian geometry-based classification models in the context of motor imagery (MI) based BCI using electroencephalography (EEG). We then propose an optimal transport theory-based approach using earth mover's distance (EMD) to quantify the comparison of the feature relevance map with the domain knowledge of neuroscience. For this, we utilized explainable AI (XAI) techniques for generating feature relevance in the spatial domain to identify important channels for model outcomes. Three state-of-the-art models are implemented - 1) Riemannian geometry-based classifier, 2) EEGNet, and 3) EEG Conformer, and the observed trend in the model's accuracy across different architectures on the dataset correlates with the proposed feature relevance metrics. The models with diverse architectures perform significantly better when trained on channels relevant to motor imagery than data-driven channel selection. This work focuses attention on the necessity for interpretability and incorporating metrics beyond accuracy, underscores the value of combining domain knowledge and quantifying model interpretations with data-driven approaches in creating reliable and robust Brain-Computer Interfaces (BCIs).
Electroencephalography (EEG) classification is a versatile and portable technique for building non-invasive Brain-computer Interfaces (BCI). However, the classifiers that decode cognitive states from EEG brain data perform poorly when tested on newer domains, such as tasks or individuals absent during model training. Researchers have recently used complex strategies like Model-agnostic meta-learning (MAML) for domain adaptation. Nevertheless, there is a need for an evaluation strategy to evaluate the fast adaptability of the models, as this characteristic is essential for real-life BCI applications for quick calibration. We used motor movement and imaginary signals as input to Convolutional Neural Networks (CNN) based classifier for the experiments. Datasets with EEG signals typically have fewer examples and higher time resolution. Even though batch-normalization is preferred for Convolutional Neural Networks (CNN), we empirically show that layer-normalization can improve the adaptability of CNN-based EEG classifiers with not more than ten fine-tuning steps. In summary, the present work (i) proposes a simple strategy to evaluate fast adaptability, and (ii) empirically demonstrate fast adaptability across individuals as well as across tasks with simple transfer learning as compared to MAML approach.
A limitation of brain-computer interface (BCI) spellers is that they require the user to be able to move the eyes to fixate on targets. This poses an issue for users who cannot voluntarily control their eye movements, for instance, people living with late-stage amyotrophic lateral sclerosis (ALS). This pilot study makes the first step towards a gaze-independent speller based on the code-modulated visual evoked potential (c-VEP). Participants were presented with two bi-laterally located stimuli, one of which was flashing, and were tasked to attend to one of these stimuli either by directly looking at the stimuli (overt condition) or by using spatial attention, eliminating the need for eye movement (covert condition). The attended stimuli were decoded from electroencephalography (EEG) and classification accuracies of 88% and 100% were obtained for the covert and overt conditions, respectively. These fundamental insights show the promising feasibility of utilizing the c-VEP protocol for gaze-independent BCIs that use covert spatial attention when both stimuli flash simultaneously.
Data scarcity in the brain-computer interface field can be alleviated through the use of generative models, specifically diffusion models. While diffusion models have previously been successfully applied to electroencephalogram (EEG) data, existing models lack flexibility w.r.t.~sampling or require alternative representations of the EEG data. To overcome these limitations, we introduce a novel approach to conditional diffusion models that utilizes classifier-free guidance to directly generate subject-, session-, and class-specific EEG data. In addition to commonly used metrics, domain-specific metrics are employed to evaluate the specificity of the generated samples. The results indicate that the proposed model can generate EEG data that resembles real data for each subject, session, and class.
Uncertainty Quantification aims to determine when the prediction from a Machine Learning model is likely to be wrong. Computer Vision research has explored methods for determining epistemic uncertainty (also known as model uncertainty), which should correspond with generalisation error. These methods theoretically allow to predict misclassifications due to inter-subject variability. We applied a variety of Uncertainty Quantification methods to predict misclassifications for a Motor Imagery Brain Computer Interface. Deep Ensembles performed best, both in terms of classification performance and cross-subject Uncertainty Quantification performance. However, we found that standard CNNs with Softmax output performed better than some of the more advanced methods.
Objective: The integration of Deep Learning (DL) algorithms on brain signal analysis is still in its nascent stages compared to their success in fields like Computer Vision. This is particularly true for BCI, where the brain activity is decoded to control external devices without requiring muscle control. Electroencephalography (EEG) is a widely adopted choice for designing BCI systems due to its non-invasive and cost-effective nature and excellent temporal resolution. Still, it comes at the expense of limited training data, poor signal-to-noise, and a large variability across and within-subject recordings. Finally, setting up a BCI system with many electrodes takes a long time, hindering the widespread adoption of reliable DL architectures in BCIs outside research laboratories. To improve adoption, we need to improve user comfort using, for instance, reliable algorithms that operate with few electrodes. Approach: Our research aims to develop a DL algorithm that delivers effective results with a limited number of electrodes. Taking advantage of the Augmented Covariance Method and the framework of SPDNet, we propose the Phase-SPDNet architecture and analyze its performance and the interpretability of the results. The evaluation is conducted on 5-fold cross-validation, using only three electrodes positioned above the Motor Cortex. The methodology was tested on nearly 100 subjects from several open-source datasets using the Mother Of All BCI Benchmark (MOABB) framework. Main results: The results of our Phase-SPDNet demonstrate that the augmented approach combined with the SPDNet significantly outperforms all the current state-of-the-art DL architecture in MI decoding. Significance: This new architecture is explainable and with a low number of trainable parameters.
Decoding language from brain dynamics is an important open direction in the realm of brain-computer interface (BCI), especially considering the rapid growth of large language models. Compared to invasive-based signals which require electrode implantation surgery, non-invasive neural signals (e.g. EEG, MEG) have attracted increasing attention considering their safety and generality. However, the exploration is not adequate in three aspects: 1) previous methods mainly focus on EEG but none of the previous works address this problem on MEG with better signal quality; 2) prior works have predominantly used $``teacher-forcing"$ during generative decoding, which is impractical; 3) prior works are mostly $``BART-based"$ not fully auto-regressive, which performs better in other sequence tasks. In this paper, we explore the brain-to-text translation of MEG signals in a speech-decoding formation. Here we are the first to investigate a cross-attention-based ``whisper" model for generating text directly from MEG signals without teacher forcing. Our model achieves impressive BLEU-1 scores of 60.30 and 52.89 without pretraining $\&$ teacher-forcing on two major datasets ($\textit{GWilliams}$ and $\textit{Schoffelen}$). This paper conducts a comprehensive review to understand how speech decoding formation performs on the neural decoding tasks, including pretraining initialization, training $\&$ evaluation set splitting, augmentation, and scaling law. Code is available at https://github.com/NeuSpeech/NeuSpeech1$.
The aim of the study is to investigate the complex mechanisms of speech perception and ultimately decode the electrical changes in the brain accruing while listening to speech. We attempt to decode heard speech from intracranial electroencephalographic (iEEG) data using deep learning methods. The goal is to aid the advancement of brain-computer interface (BCI) technology for speech synthesis, and, hopefully, to provide an additional perspective on the cognitive processes of speech perception. This approach diverges from the conventional focus on speech production and instead chooses to investigate neural representations of perceived speech. This angle opened up a complex perspective, potentially allowing us to study more sophisticated neural patterns. Leveraging the power of deep learning models, the research aimed to establish a connection between these intricate neural activities and the corresponding speech sounds. Despite the approach not having achieved a breakthrough yet, the research sheds light on the potential of decoding neural activity during speech perception. Our current efforts can serve as a foundation, and we are optimistic about the potential of expanding and improving upon this work to move closer towards more advanced BCIs, better understanding of processes underlying perceived speech and its relation to spoken speech.
Electroencephalography (EEG) plays a vital role in recording brain activities and is integral to the development of brain-computer interface (BCI) technologies. However, the limited availability and high variability of EEG signals present substantial challenges in creating reliable BCIs. To address this issue, we propose a practical solution drawing on the latest developments in deep learning and Wasserstein Generative Adversarial Network (WGAN). The WGAN was trained on the BCI2000 dataset, consisting of around 1500 EEG recordings and 64 channels from 45 individuals. The generated EEG signals were evaluated via three classifiers yielding improved average accuracies. The quality of generated signals measured using Frechet Inception Distance (FID) yielded scores of 1.345 and 11.565 for eyes-open and closed respectively. Even without a spectral or spatial loss term, our WGAN model was able to emulate the spectral and spatial properties of the EEG training data. The WGAN-generated data mirrored the dominant alpha activity during closed-eye resting and high delta waves in the training data in its topographic map and power spectral density (PSD) plot. Our research testifies to the potential of WGANs in addressing the limited EEG data issue for BCI development by enhancing a small dataset to improve classifier generalizability.
Various new brain-computer interface technologies or neuroscience applications require decoding stimulus-following neural responses to natural stimuli such as speech and video from, e.g., electroencephalography (EEG) signals. In this context, generalized canonical correlation analysis (GCCA) is often used as a group analysis technique, which allows the extraction of correlated signal components from the neural activity of multiple subjects attending to the same stimulus. GCCA can be used to improve the signal-to-noise ratio of the stimulus-following neural responses relative to all other irrelevant (non-)neural activity, or to quantify the correlated neural activity across multiple subjects in a group-wise coherence metric. However, the traditional GCCA technique is stimulus-unaware: no information about the stimulus is used to estimate the correlated components from the neural data of several subjects. Therefore, the GCCA technique might fail to extract relevant correlated signal components in practical situations where the amount of information is limited, for example, because of a limited amount of training data or group size. This motivates a new stimulus-informed GCCA (SI-GCCA) framework that allows taking the stimulus into account to extract the correlated components. We show that SI-GCCA outperforms GCCA in various practical settings, for both auditory and visual stimuli. Moreover, we showcase how SI-GCCA can be used to steer the estimation of the components towards the stimulus. As such, SI-GCCA substantially improves upon GCCA for various purposes, ranging from preprocessing to quantifying attention.
The Rapid Serial Visual Presentation (RSVP)-based Brain-Computer Interface (BCI) is an efficient technology for target retrieval using electroencephalography (EEG) signals. The performance improvement of traditional decoding methods relies on a substantial amount of training data from new test subjects, which increases preparation time for BCI systems. Several studies introduce data from existing subjects to reduce the dependence of performance improvement on data from new subjects, but their optimization strategy based on adversarial learning with extensive data increases training time during the preparation procedure. Moreover, most previous methods only focus on the single-view information of EEG signals, but ignore the information from other views which may further improve performance. To enhance decoding performance while reducing preparation time, we propose a Temporal-Spectral fusion transformer with Subject-specific Adapter (TSformer-SA). Specifically, a cross-view interaction module is proposed to facilitate information transfer and extract common representations across two-view features extracted from EEG temporal signals and spectrogram images. Then, an attention-based fusion module fuses the features of two views to obtain comprehensive discriminative features for classification. Furthermore, a multi-view consistency loss is proposed to maximize the feature similarity between two views of the same EEG signal. Finally, we propose a subject-specific adapter to rapidly transfer the knowledge of the model trained on data from existing subjects to decode data from new subjects. Experimental results show that TSformer-SA significantly outperforms comparison methods and achieves outstanding performance with limited training data from new subjects. This facilitates efficient decoding and rapid deployment of BCI systems in practical use.
In the era of Artificial Intelligence Generated Content (AIGC), conditional multimodal synthesis technologies (e.g., text-to-image, text-to-video, text-to-audio, etc) are gradually reshaping the natural content in the real world. The key to multimodal synthesis technology is to establish the mapping relationship between different modalities. Brain signals, serving as potential reflections of how the brain interprets external information, exhibit a distinctive One-to-Many correspondence with various external modalities. This correspondence makes brain signals emerge as a promising guiding condition for multimodal content synthesis. Brian-conditional multimodal synthesis refers to decoding brain signals back to perceptual experience, which is crucial for developing practical brain-computer interface systems and unraveling complex mechanisms underlying how the brain perceives and comprehends external stimuli. This survey comprehensively examines the emerging field of AIGC-based Brain-conditional Multimodal Synthesis, termed AIGC-Brain, to delineate the current landscape and future directions. To begin, related brain neuroimaging datasets, functional brain regions, and mainstream generative models are introduced as the foundation of AIGC-Brain decoding and analysis. Next, we provide a comprehensive taxonomy for AIGC-Brain decoding models and present task-specific representative work and detailed implementation strategies to facilitate comparison and in-depth analysis. Quality assessments are then introduced for both qualitative and quantitative evaluation. Finally, this survey explores insights gained, providing current challenges and outlining prospects of AIGC-Brain. Being the inaugural survey in this domain, this paper paves the way for the progress of AIGC-Brain research, offering a foundational overview to guide future work.
Electroencephalography (EEG) signals are easily corrupted by various artifacts, making artifact removal crucial for improving signal quality in scenarios such as disease diagnosis and brain-computer interface (BCI). In this paper, we present a fully convolutional neural architecture, called DTP-Net, which consists of a Densely Connected Temporal Pyramid (DTP) sandwiched between a pair of learnable time-frequency transformations for end-to-end electroencephalogram (EEG) denoising. The proposed method first transforms a single-channel EEG signal of arbitrary length into the time-frequency domain via an Encoder layer. Then, noises, such as ocular and muscle artifacts, are extracted by DTP in a multi-scale fashion and reduced. Finally, a Decoder layer is employed to reconstruct the artifact-reduced EEG signal. Additionally, we conduct an in-depth analysis of the representation learning behavior of each module in DTP-Net to substantiate its robustness and reliability. Extensive experiments conducted on two public semi-simulated datasets demonstrate the effective artifact removal performance of DTP-Net, which outperforms state-of-art approaches. Experimental results demonstrate cleaner waveforms and significant improvement in Signal-to-Noise Ratio (SNR) and Relative Root Mean Square Error (RRMSE) after denoised by the proposed model. Moreover, the proposed DTP-Net is applied in a specific BCI downstream task, improving the classification accuracy by up to 5.55% compared to that of the raw signals, validating its potential applications in the fields of EEG-based neuroscience and neuro-engineering.
The Relevance Feedback (RF) process relies on accurate and real-time relevance estimation of feedback documents to improve retrieval performance. Since collecting explicit relevance annotations imposes an extra burden on the user, extensive studies have explored using pseudo-relevance signals and implicit feedback signals as substitutes. However, such signals are indirect indicators of relevance and suffer from complex search scenarios where user interactions are absent or biased. Recently, the advances in portable and high-precision brain-computer interface (BCI) devices have shown the possibility to monitor user's brain activities during search process. Brain signals can directly reflect user's psychological responses to search results and thus it can act as additional and unbiased RF signals. To explore the effectiveness of brain signals in the context of RF, we propose a novel RF framework that combines BCI-based relevance feedback with pseudo-relevance signals and implicit signals to improve the performance of document re-ranking. The experimental results on the user study dataset show that incorporating brain signals leads to significant performance improvement in our RF framework. Besides, we observe that brain signals perform particularly well in several hard search scenarios, especially when implicit signals as feedback are missing or noisy. This reveals when and how to exploit brain signals in the context of RF.
Motor imagery EEG classification plays a crucial role in non-invasive Brain-Computer Interface (BCI) research. However, the classification is affected by the non-stationarity and individual variations of EEG signals. Simply pooling EEG data with different statistical distributions to train a classification model can severely degrade the generalization performance. To address this issue, the existing methods primarily focus on domain adaptation, which requires access to the target data during training. This is unrealistic in many EEG application scenarios. In this paper, we propose a novel multi-source domain generalization framework called EEG-DG, which leverages multiple source domains with different statistical distributions to build generalizable models on unseen target EEG data. We optimize both the marginal and conditional distributions to ensure the stability of the joint distribution across source domains and extend it to a multi-source domain generalization framework to achieve domain-invariant feature representation, thereby alleviating calibration efforts. Systematic experiments on a simulative dataset and BCI competition datasets IV-2a and IV-2b demonstrate the superiority of our proposed EEG-DG over state-of-the-art methods. Specifically, EEG-DG achieves an average classification accuracy/kappa value of 81.79%/0.7572 and 87.12%/0.7424 on datasets IV-2a and IV-2b, respectively, which even outperforms some domain adaptation methods. Our code is available at https://github.com/XC-ZhongHIT/EEG-DG for free download and evaluation.
To handle the scarcity and heterogeneity of electroencephalography (EEG) data for Brain-Computer Interface (BCI) tasks, and to harness the power of large publicly available data sets, we propose Neuro-GPT, a foundation model consisting of an EEG encoder and a GPT model. The foundation model is pre-trained on a large-scale data set using a self-supervised task that learns how to reconstruct masked EEG segments. We then fine-tune the model on a Motor Imagery Classification task to validate its performance in a low-data regime (9 subjects). Our experiments demonstrate that applying a foundation model can significantly improve classification performance compared to a model trained from scratch, which provides evidence for the generalizability of the foundation model and its ability to address challenges of data scarcity and heterogeneity in EEG. The code is publicly available at github.com/wenhui0206/NeuroGPT.
The objective of this study is to investigate the application of various channel attention mechanisms within the domain of brain-computer interface (BCI) for motor imagery decoding. Channel attention mechanisms can be seen as a powerful evolution of spatial filters traditionally used for motor imagery decoding. This study systematically compares such mechanisms by integrating them into a lightweight architecture framework to evaluate their impact. We carefully construct a straightforward and lightweight baseline architecture designed to seamlessly integrate different channel attention mechanisms. This approach is contrary to previous works which only investigate one attention mechanism and usually build a very complex, sometimes nested architecture. Our framework allows us to evaluate and compare the impact of different attention mechanisms under the same circumstances. The easy integration of different channel attention mechanisms as well as the low computational complexity enables us to conduct a wide range of experiments on four datasets to thoroughly assess the effectiveness of the baseline model and the attention mechanisms. Our experiments demonstrate the strength and generalizability of our architecture framework as well as how channel attention mechanisms can improve the performance while maintaining the small memory footprint and low computational complexity of our baseline architecture. Our architecture emphasizes simplicity, offering easy integration of channel attention mechanisms, while maintaining a high degree of generalizability across datasets, making it a versatile and efficient solution for EEG motor imagery decoding within brain-computer interfaces.
Brain-Computer Interface (BCI) systems allow users to perform actions by translating their brain activity into commands. Such systems usually need a training phase, consisting in training a classification algorithm to discriminate between mental states using specific features from the recorded signals. This phase of feature selection and training is crucial for BCI performance and presents specific constraints to be met in a clinical context, such as post-stroke rehabilitation. In this paper, we present HappyFeat, a software making Motor Imagery (MI) based BCI experiments easier, by gathering all necessary manipulations and analysis in a single convenient GUI and via automation of experiment or analysis parameters. The resulting workflow allows for effortlessly selecting the best features, helping to achieve good BCI performance in time-constrained environments. Alternative features based on Functional Connectivity can be used and compared or combined with Power Spectral Density, allowing a network-oriented approach. We then give details of HappyFeat's main mechanisms, and a review of its performances in typical use cases. We also show that it can be used as an efficient tool for comparing different metrics extracted from the signals, to train the classification algorithm. To this end, we show a comparison between the commonly-used Power Spectral Density and network metrics based on Functional Connectivity. HappyFeat is available as an open-source project which can be freely downloaded on GitHub.