Nuclear segmentation and classification within Haematoxylin & Eosin stained histology images is a fundamental prerequisite in the digital pathology work-flow. The development of automated methods for nuclear segmentation and classification enables the quantitative analysis of tens of thousands of nuclei within a whole-slide pathology image, opening up possibilities of further analysis of large-scale nuclear morphometry. However, automated nuclear segmentation and classification is faced with a major challenge in that there are several different types of nuclei, some of them exhibiting large intra-class variability such as the tumour cells. Additionally, some of the nuclei are often clustered together. To address these challenges, we present a novel convolutional neural network for simultaneous nuclear segmentation and classification that leverages the instance-rich information encoded within the vertical and horizontal distances of nuclear pixels to their centres of mass. These distances are then utilised to separate clustered nuclei, resulting in an accurate segmentation, particularly in areas with overlapping instances. Then for each segmented instance, the network predicts the type of nucleus via a devoted up-sampling branch. We demonstrate state-of-the-art performance compared to other methods on multiple independent multi-tissue histology image datasets. As part of this work, we introduce a new dataset of Haematoxylin & Eosin stained colorectal adenocarcinoma image tiles, containing 24,319 exhaustively annotated nuclei with associated class labels.
This paper presents a simple yet effective supervised deep hash approach that constructs binary hash codes from labeled data for large-scale image search. We assume that the semantic labels are governed by several latent attributes with each attribute on or off, and classification relies on these attributes. Based on this assumption, our approach, dubbed supervised semantics-preserving deep hashing (SSDH), constructs hash functions as a latent layer in a deep network and the binary codes are learned by minimizing an objective function defined over classification error and other desirable hash codes properties. With this design, SSDH has a nice characteristic that classification and retrieval are unified in a single learning model. Moreover, SSDH performs joint learning of image representations, hash codes, and classification in a point-wised manner, and thus is scalable to large-scale datasets. SSDH is simple and can be realized by a slight enhancement of an existing deep architecture for classification; yet it is effective and outperforms other hashing approaches on several benchmarks and large datasets. Compared with state-of-the-art approaches, SSDH achieves higher retrieval accuracy, while the classification performance is not sacrificed.
Hashing methods have been widely used for applications of large-scale image retrieval and classification. Non-deep hashing methods using handcrafted features have been significantly outperformed by deep hashing methods due to their better feature representation and end-to-end learning framework. However, the most striking successes in deep hashing have mostly involved discriminative models, which require labels. In this paper, we propose a novel unsupervised deep hashing method, named Deep Discrete Hashing (DDH), for large-scale image retrieval and classification. In the proposed framework, we address two main problems: 1) how to directly learn discrete binary codes? 2) how to equip the binary representation with the ability of accurate image retrieval and classification in an unsupervised way? We resolve these problems by introducing an intermediate variable and a loss function steering the learning process, which is based on the neighborhood structure in the original space. Experimental results on standard datasets (CIFAR-10, NUS-WIDE, and Oxford-17) demonstrate that our DDH significantly outperforms existing hashing methods by large margin in terms of~mAP for image retrieval and object recognition. Code is available at \url{https://github.com/htconquer/ddh}.
Few-shot image classification has recently witnessed the rise of representation learning being utilised for models to adapt to new classes using only a few training examples. Therefore, the properties of the representations, such as their underlying probability distributions, assume vital importance. Representations sampled from Gaussian distributions have been used in recent works, [19] to train classifiers for few-shot classification. These methods rely on transforming the distributions of experimental data to approximate Gaussian distributions for their functioning. In this paper, I propose a novel Gaussian transform, that outperforms existing methods on transforming experimental data into Gaussian-like distributions. I then utilise this novel transformation for few-shot image classification and show significant gains in performance, while sampling lesser data.
Geometric shape features have been widely used as strong predictors for image classification. Nevertheless, most existing classifiers such as deep neural networks (DNNs) directly leverage the statistical correlations between these shape features and target variables. However, these correlations can often be spurious and unstable across different environments (e.g., in different age groups, certain types of brain changes have unstable relations with neurodegenerative disease); hence leading to biased or inaccurate predictions. In this paper, we introduce a novel framework that for the first time develops invariant shape representation learning (ISRL) to further strengthen the robustness of image classifiers. In contrast to existing approaches that mainly derive features in the image space, our model ISRL is designed to jointly capture invariant features in latent shape spaces parameterized by deformable transformations. To achieve this goal, we develop a new learning paradigm based on invariant risk minimization (IRM) to learn invariant representations of image and shape features across multiple training distributions/environments. By embedding the features that are invariant with regard to target variables in different environments, our model consistently offers more accurate predictions. We validate our method by performing classification tasks on both simulated 2D images, real 3D brain and cine cardiovascular magnetic resonance images (MRIs). Our code is publicly available at https://github.com/tonmoy-hossain/ISRL.
The recent success of the generative model shows that leveraging the multi-modal embedding space can manipulate an image using text information. However, manipulating an image with other sources rather than text, such as sound, is not easy due to the dynamic characteristics of the sources. Especially, sound can convey vivid emotions and dynamic expressions of the real world. Here, we propose a framework that directly encodes sound into the multi-modal (image-text) embedding space and manipulates an image from the space. Our audio encoder is trained to produce a latent representation from an audio input, which is forced to be aligned with image and text representations in the multi-modal embedding space. We use a direct latent optimization method based on aligned embeddings for sound-guided image manipulation. We also show that our method can mix text and audio modalities, which enrich the variety of the image modification. We verify the effectiveness of our sound-guided image manipulation quantitatively and qualitatively. We also show that our method can mix different modalities, i.e., text and audio, which enrich the variety of the image modification. The experiments on zero-shot audio classification and semantic-level image classification show that our proposed model outperforms other text and sound-guided state-of-the-art methods.
Before the recent success of deep learning methods for automated medical image analysis, practitioners used handcrafted radiomic features to quantitatively describe local patches of medical images. However, extracting discriminative radiomic features relies on accurate pathology localization, which is difficult to acquire in real-world settings. Despite advances in disease classification and localization from chest X-rays, many approaches fail to incorporate clinically-informed domain knowledge. For these reasons, we propose a Radiomics-Guided Transformer (RGT) that fuses \textit{global} image information with \textit{local} knowledge-guided radiomics information to provide accurate cardiopulmonary pathology localization and classification \textit{without any bounding box annotations}. RGT consists of an image Transformer branch, a radiomics Transformer branch, and fusion layers that aggregate image and radiomic information. Using the learned self-attention of its image branch, RGT extracts a bounding box for which to compute radiomic features, which are further processed by the radiomics branch; learned image and radiomic features are then fused and mutually interact via cross-attention layers. Thus, RGT utilizes a novel end-to-end feedback loop that can bootstrap accurate pathology localization only using image-level disease labels. Experiments on the NIH ChestXRay dataset demonstrate that RGT outperforms prior works in weakly supervised disease localization (by an average margin of 3.6\% over various intersection-over-union thresholds) and classification (by 1.1\% in average area under the receiver operating characteristic curve). We publicly release our codes and pre-trained models at \url{https://github.com/VITA-Group/chext}.
In this paper, we aim at addressing two critical issues in the 3D detection task, including the exploitation of multiple sensors~(namely LiDAR point cloud and camera image), as well as the inconsistency between the localization and classification confidence. To this end, we propose a novel fusion module to enhance the point features with semantic image features in a point-wise manner without any image annotations. Besides, a consistency enforcing loss is employed to explicitly encourage the consistency of both the localization and classification confidence. We design an end-to-end learnable framework named EPNet to integrate these two components. Extensive experiments on the KITTI and SUN-RGBD datasets demonstrate the superiority of EPNet over the state-of-the-art methods. Codes and models are available at: \url{https://github.com/happinesslz/EPNet}.
Deep neural networks have been widely used in computer vision. There are several well trained deep neural networks for the ImageNet classification challenge, which has played a significant role in image recognition. However, little work has explored pre-trained neural networks for image recognition in domain adaption. In this paper, we are the first to extract better-represented features from a pre-trained Inception ResNet model for domain adaptation. We then present a modified distribution alignment method for classification using the extracted features. We test our model using three benchmark datasets (Office+Caltech-10, Office-31, and Office-Home). Extensive experiments demonstrate significant improvements (4.8%, 5.5%, and 10%) in classification accuracy over the state-of-the-art.
Automatic bill classification is an attractive task with many potential applications such as automated detection and counting in images or videos. To address this purpose we present a Deep Learning Model to classify Chilean Banknotes, because of its successful results in image processing applications. For optimal performance of the proposed model, data augmentation techniques are introduced due to the limited number of image samples. Positive results were achieved in this work, verifying that it could be a stating point to be extended to more complex applications.
This short paper presents preliminary research on the Case-Enhanced Vision Transformer (CEViT), a similarity measurement method aimed at improving the explainability of similarity assessments for image data. Initial experimental results suggest that integrating CEViT into k-Nearest Neighbor (k-NN) classification yields classification accuracy comparable to state-of-the-art computer vision models, while adding capabilities for illustrating differences between classes. CEViT explanations can be influenced by prior cases, to illustrate aspects of similarity relevant to those cases.
The exponential growth in the number of complex datasets every year requires more enhancement in machine learning methods to provide robust and accurate data classification. Lately, deep learning approaches have achieved surpassing results in comparison to previous machine learning algorithms. However, finding the suitable structure for these models has been a challenge for researchers. This paper introduces Random Multimodel Deep Learning (RMDL): a new ensemble, deep learning approach for classification. RMDL solves the problem of finding the best deep learning structure and architecture while simultaneously improving robustness and accuracy through ensembles of deep learning architectures. In short, RMDL trains multiple randomly generated models of Deep Neural Network (DNN), Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN) in parallel and combines their results to produce better result of any of those models individually. In this paper, we describe RMDL model and compare the results for image and text classification as well as face recognition. We used MNIST and CIFAR-10 datasets as ground truth datasets for image classification and WOS, Reuters, IMDB, and 20newsgroup datasets for text classification. Lastly, we used ORL dataset to compare the model performance on face recognition task.
Efficiently implementing remote sensing image classification with high spatial resolution imagery can provide a significant value in Land Use and Land Cover (LULC) classification. The new advances in remote sensing and deep learning technologies have facilitated the extraction of spatiotemporal information for LULC classification. Moreover, the diverse disciplines of science, including remote sensing, have utilised tremendous improvements in image classification by Convolutional Neural Networks (CNNs) with transfer learning. In this study, instead of training CNNs from scratch, the transfer learning is applied to fine-tune pre-trained networks Visual Geometry Group (VGG16) and Wide Residual Networks (WRNs), by replacing the final layer with additional layers, for LULC classification using the red-green-blue version of the EuroSAT dataset. Moreover, the performance and computational time are compared and optimised with techniques, such as early stopping, gradient clipping, adaptive learning rates, and data augmentation. The proposed approaches have addressed the limited-data problem, and very good accuracies are achieved. The results show that the proposed method based on the WRNs performs better than the previous best-stated results in terms of the computational efficiency and accuracy from 98.57% to 99.17%.
Deep hashing methods have been shown to be the most efficient approximate nearest neighbor search techniques for large-scale image retrieval. However, existing deep hashing methods have a poor small-sample ranking performance for case-based medical image retrieval. The top-ranked images in the returned query results may be as a different class than the query image. This ranking problem is caused by classification, regions of interest (ROI), and small-sample information loss in the hashing space. To address the ranking problem, we propose an end-to-end framework, called Attention-based Triplet Hashing (ATH) network, to learn low-dimensional hash codes that preserve the classification, ROI, and small-sample information. We embed a spatial-attention module into the network structure of our ATH to focus on ROI information. The spatial-attention module aggregates the spatial information of feature maps by utilizing max-pooling, element-wise maximum, and element-wise mean operations jointly along the channel axis. The triplet cross-entropy loss can help to map the classification information of images and similarity between images into the hash codes. Extensive experiments on two case-based medical datasets demonstrate that our proposed ATH can further improve the retrieval performance compared to the state-of-the-art deep hashing methods and boost the ranking performance for small samples. Compared to the other loss methods, the triplet cross-entropy loss can enhance the classification performance and hash code-discriminability
Deep learning-based histopathology image classification is a key technique to help physicians in improving the accuracy and promptness of cancer diagnosis. However, the noisy labels are often inevitable in the complex manual annotation process, and thus mislead the training of the classification model. In this work, we introduce a novel hard sample aware noise robust learning method for histopathology image classification. To distinguish the informative hard samples from the harmful noisy ones, we build an easy/hard/noisy (EHN) detection model by using the sample training history. Then we integrate the EHN into a self-training architecture to lower the noise rate through gradually label correction. With the obtained almost clean dataset, we further propose a noise suppressing and hard enhancing (NSHE) scheme to train the noise robust model. Compared with the previous works, our method can save more clean samples and can be directly applied to the real-world noisy dataset scenario without using a clean subset. Experimental results demonstrate that the proposed scheme outperforms the current state-of-the-art methods in both the synthetic and real-world noisy datasets. The source code and data are available at https://github.com/bupt-ai-cz/HSA-NRL/.
The recent introduction of prompt tuning based on pre-trained vision-language models has dramatically improved the performance of multi-label image classification. However, some existing strategies that have been explored still have drawbacks, i.e., either exploiting massive labeled visual data at a high cost or using text data only for text prompt tuning and thus failing to learn the diversity of visual knowledge. Hence, the application scenarios of these methods are limited. In this paper, we propose a pseudo-visual prompt~(PVP) module for implicit visual prompt tuning to address this problem. Specifically, we first learn the pseudo-visual prompt for each category, mining diverse visual knowledge by the well-aligned space of pre-trained vision-language models. Then, a co-learning strategy with a dual-adapter module is designed to transfer visual knowledge from pseudo-visual prompt to text prompt, enhancing their visual representation abilities. Experimental results on VOC2007, MS-COCO, and NUSWIDE datasets demonstrate that our method can surpass state-of-the-art~(SOTA) methods across various settings for multi-label image classification tasks. The code is available at https://github.com/njustkmg/PVP.
Contrastive learning has proven effective for pre-training image models on unlabeled data with promising results for tasks such as medical image classification. Using paired text (like radiological reports) during pre-training improves the results even further. Still, most existing methods target image classification downstream tasks and may not be optimal for localized tasks like semantic segmentation or object detection. We therefore propose Localized representation learning from Vision and Text (LoVT), to our best knowledge, the first text-supervised pre-training method that targets localized medical imaging tasks. Our method combines instance-level image-report contrastive learning with local contrastive learning on image region and report sentence representations. We evaluate LoVT and commonly used pre-training methods on an evaluation framework of 18 localized tasks on chest X-rays from five public datasets. LoVT performs best on 10 of the 18 studied tasks making it the preferred method of choice for localized tasks.
Motion artefacts in magnetic resonance brain images can have a strong impact on diagnostic confidence. The assessment of MR image quality is fundamental before proceeding with the clinical diagnosis. Motion artefacts can alter the delineation of structures such as the brain, lesions or tumours and may require a repeat scan. Otherwise, an inaccurate (e.g. correct pathology but wrong severity) or incorrect diagnosis (e.g. wrong pathology) may occur. "\textit{Image quality assessment}" as a fast, automated step right after scanning can assist in deciding if the acquired images are diagnostically sufficient. An automated image quality assessment based on the structural similarity index (SSIM) regression through a residual neural network is proposed in this work. Additionally, a classification into different groups - by subdividing with SSIM ranges - is evaluated. Importantly, this method predicts SSIM values of an input image in the absence of a reference ground truth image. The networks were able to detect motion artefacts, and the best performance for the regression and classification task has always been achieved with ResNet-18 with contrast augmentation. The mean and standard deviation of residuals' distribution were $\mu=-0.0009$ and $\sigma=0.0139$, respectively. Whilst for the classification task in 3, 5 and 10 classes, the best accuracies were 97, 95 and 89\%, respectively. The results show that the proposed method could be a tool for supporting neuro-radiologists and radiographers in evaluating image quality quickly.
Deep neural networks face several challenges in hyperspectral image classification, including insufficient utilization of joint spatial-spectral information, gradient vanishing with increasing depth, and overfitting. To enhance feature extraction efficiency while skipping redundant information, this paper proposes a dynamic attention convolution design based on an improved 3D-DenseNet model. The design employs multiple parallel convolutional kernels instead of a single kernel and assigns dynamic attention weights to these parallel convolutions. This dynamic attention mechanism achieves adaptive feature response based on spatial characteristics in the spatial dimension of hyperspectral images, focusing more on key spatial structures. In the spectral dimension, it enables dynamic discrimination of different bands, alleviating information redundancy and computational complexity caused by high spectral dimensionality. The DAC module enhances model representation capability by attention-based aggregation of multiple convolutional kernels without increasing network depth or width. The proposed method demonstrates superior performance in both inference speed and accuracy, outperforming mainstream hyperspectral image classification methods on the IN, UP, and KSC datasets.
Multiple instance learning (MIL) is a powerful tool to solve the weakly supervised classification in whole slide image (WSI) based pathology diagnosis. However, the current MIL methods are usually based on independent and identical distribution hypothesis, thus neglect the correlation among different instances. To address this problem, we proposed a new framework, called correlated MIL, and provided a proof for convergence. Based on this framework, we devised a Transformer based MIL (TransMIL), which explored both morphological and spatial information. The proposed TransMIL can effectively deal with unbalanced/balanced and binary/multiple classification with great visualization and interpretability. We conducted various experiments for three different computational pathology problems and achieved better performance and faster convergence compared with state-of-the-art methods. The test AUC for the binary tumor classification can be up to 93.09% over CAMELYON16 dataset. And the AUC over the cancer subtypes classification can be up to 96.03% and 98.82% over TCGA-NSCLC dataset and TCGA-RCC dataset, respectively. Implementation is available at: https://github.com/szc19990412/TransMIL.